Many people linked her response to her previous relationship with Maps Maponyane.
In between the laughing and the head scratching, Nomzamo said; "I don't know what you're talking about, OK. We are strong. We are moving. Don't know her. What do you mean?... this is tough...What is a heartbreak? Is it a name of a street? Is it a mall? What is it?"
The actress has since muted her Twitter account following topping the trends list on Monday.
Anele took to Twitter to slam the trolls and said she is probably going through the most whilst she is in the states alone and receiving such vile treatment from back home.
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Her manager also slammed trolls and said the actress was just having some innocent fun.
Phumza Nohashe said "Anyone with half a brain and being an authentic follower of hers should see that Nomzamo is a fun and lighthearted person, and suffers no more issues than the unqualified Twitter psychologists who are currently diagnosing her every facial muscle movement."