Bonang Matheba, Sizwe Dhlomo and Siyabonga Ngwekazi are set to leave youth radio station YFM, at the end of the month.
This move comes as a "dramatic overhaul" of the station's lineup for the next year, which is starting in April.
YFM Programming Manager, Tumelo Diaho-Monaheng, said that Bonang, Sizwe and Siyabonga would be leaving after 5 years on air.
Matheba said: "I have had an incredible 5 years at YFM, building some awesome relationships with my listeners on the station. During this time my brand has grown in leaps and bounds, both as an artist and as a business woman."
"The next chapter in my life is all about strengthening my craft and elevating my offering and platforms like never before," she added.
According to DRUM, Diaho-Monaheng, described Matheba as "one of the most talented individuals of recent times" but said the lineup changes were part of the programme strategy.
"As a youth radio station we are continuously identifying and honing our on air talent to resonate with our young audience," added Diaho-Monaheng.